Description

5-Chloro-2,3-difluoropyridine is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen and fluorine atoms on the pyridine ring, which enables precise molecular modifications for developing novel compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoropyridine core enhances bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom chemical synthesis services catering to R&D and scale-up projects.

Basic Information

Product Name	5-Chloro-2,3-difluoropyridine
CAS No.	89402-43-7
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	2,3-Difluoro-5-chloropyridine; 5-Chloro-2,3-difluoropyridine; 2,3-Difluoro-5-chloro-pyridine; Pyridine, 5-chloro-2,3-difluoro-; 89402-43-7
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-difluoropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.