Description

1-Benzyl Hydrogen (S)-4-Phthalimidoglutarate is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for the preparation of complex pharmaceutical compounds, particularly those targeting neurological and cardiovascular pathways. This product is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug molecules, particularly for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and enzyme inhibitors due to its glutaric acid backbone and protected amine functionality.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to introduce stereochemical complexity.
• Protease Inhibitor Development: Employed in the research and development of inhibitors for various proteolytic enzymes.
• Custom Synthesis & CDMO Services: A valuable compound for contract research and manufacturing organizations offering bespoke synthetic routes for clients.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-Benzyl Hydrogen (S)-4-Phthalimidoglutarate
CAS No.	88784-33-2
Molecular Formula	C20H17NO6
Molecular Weight	367.35 g/mol
Synonyms	(S)-1-Benzyl 5-hydrogen 4-phthalimidopentanedioate; (S)-4-Phthalimidoglutaric Acid 1-Benzyl Ester; Benzyl (S)-4-Phthalimidoglutarate; (S)-1-Benzyl 4-Phthalimidoglutarate; L-4-Phthalimidoglutaric Acid 1-Benzyl Ester; N-Phthaloyl-L-glutamic Acid α-Benzyl Ester; Bn-OPhtGlu-OH
EINECS	Contact for details

Quality Control

Our 1-Benzyl Hydrogen (S)-4-Phthalimidoglutarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.