Description

1-Phenyl-4-Trimethylsilanyl-But-3-Yn-2-One is a specialized organosilicon building block featuring a phenylacetylene moiety protected by a trimethylsilyl (TMS) group. This compound is valued for its role as a versatile synthon in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring acetylene or arylacetylene motifs.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides where the TMS-protected alkyne allows for selective functionalization.
• Material Science Research: Serves as a precursor in the development of organic semiconductors, liquid crystals, and other functional organic materials.
• Cross-Coupling Reactions: An essential substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Reagent: Employed in academic and industrial R&D labs for the construction of complex natural products and molecular scaffolds.
• Chemical Derivatization: Used to introduce the phenylacetylene functional group into larger molecules after deprotection of the TMS group.

Basic Information

Product Name	1-Phenyl-4-Trimethylsilanyl-But-3-Yn-2-One
CAS No.	88768-84-7
Molecular Formula	C₁₃H₁₆OSi
Molecular Weight	216.35 g/mol
Synonyms	4-(Trimethylsilyl)-1-phenyl-3-butyn-2-one; 1-Phenyl-4-(trimethylsilyl)-3-butyn-2-one; 3-Butyn-2-one, 1-phenyl-4-(trimethylsilyl)-; TMS Phenylacetylene Ketone; (Phenylethynyl)trimethylsilyl Methyl Ketone; 4-Trimethylsilyl-1-phenylbut-3-yn-2-one
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-4-Trimethylsilanyl-But-3-Yn-2-One adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-compliant manufacturing for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.