Description

9-Fluorenylmethyl Pentafluorophenyl Carbonate (CAS NO 88744-04-1) is a highly reactive and specialized chemical reagent primarily used in advanced organic synthesis and peptide chemistry. Its core value lies in its dual functionality, serving as an efficient coupling agent and a protecting group activator, which is critical for constructing complex molecules with high fidelity. This compound is essential for researchers and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and development.

Application

• Peptide Synthesis: Acts as a key coupling reagent in solid-phase and solution-phase peptide synthesis, facilitating the formation of amide bonds.
• Protecting Group Chemistry: Used for the introduction and manipulation of the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, a cornerstone of modern peptide assembly.
• Bioconjugation: Enables the selective labeling and modification of biomolecules such as proteins and oligonucleotides for diagnostic and therapeutic applications.
• Polymer Chemistry: Serves as a monomer or functionalization agent in the synthesis of specialized polymers and dendrimers.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Chemical Biology Research: Utilized in probe development and activity-based protein profiling to study enzyme function and mechanisms.

Basic Information

Product Name	9-Fluorenylmethyl Pentafluorophenyl Carbonate
CAS No.	88744-04-1
Molecular Formula	C21H11F5O3
Molecular Weight	406.31 g/mol
Synonyms	Fmoc-OPfp; Fmoc-Pentafluorophenyl Carbonate; 9H-Fluoren-9-ylmethyl Pentafluorophenyl Carbonate; Pentafluorophenyl 9-Fluorenylmethyl Carbonate; N-(9-Fluorenylmethoxycarbonyloxy)pentafluorobenzene; Fmoc-OPh(CF3)2; Fmoc-O-Pfp; Fmoc Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our 9-Fluorenylmethyl Pentafluorophenyl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.