Description

Diethyl 2-Phthalimidomalonate-2-13C is a stable isotope-labeled derivative of diethyl phthalimidomalonate, where the carbon atom at the 2-position is enriched with the 13C isotope. This compound is a critical synthetic intermediate, valued for its role in the preparation of isotopically labeled amino acids and other complex organic molecules for research and development. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and academic institutions engaged in advanced synthesis, metabolic studies, and analytical method development.

Application

• Synthesis of 13C-Labeled Amino Acids: A key precursor for the production of isotopically labeled amino acids like glycine, alanine, and serine for use as internal standards in mass spectrometry.
• Pharmaceutical Research & Development: Used in the synthesis of isotopically labeled drug candidates and metabolites for pharmacokinetic (PK), pharmacodynamic (PD), and absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Serves as a building block for compounds used to trace and elucidate biochemical pathways in biological systems.
• Analytical Standard Development: Employed in the development and calibration of high-precision analytical methods, including LC-MS and NMR spectroscopy.
• Agrochemical Research: Used in the synthesis of labeled analogs of pesticides or herbicides for environmental fate and degradation studies.
• Organic Synthesis Intermediate: Functions as a versatile reagent in various organic synthesis protocols requiring the phthalimido and malonate functional groups.

Basic Information

Product Name	Diethyl 2-Phthalimidomalonate-2-13C
CAS No.	88596-93-4
Molecular Formula	C15H15NO6 (with 13C at specified position)
Molecular Weight	~307.29 g/mol (13C adjusted)
Synonyms	Diethyl (phthalimido)(13C)malonate; Diethyl (13C)phthalimidomalonate; 2-Phthalimidomalonic Acid Diethyl Ester-2-13C; DEPM-2-13C; Diethyl (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)(13C)propanedioate; Malonic acid, (1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, diethyl ester, 2-13C; Diethyl 2-(1,3-dioxoisoindolin-2-yl)(13C)malonate
EINECS	Contact for details

Quality Control

Our Diethyl 2-Phthalimidomalonate-2-13C is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. Key parameters verified include assay (by HPLC or NMR), isotopic purity (by MS), and identification (by IR and NMR). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C signal present)
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99 atom % 13C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.