Description

Bis(Hydroxybenzotriazolyl) Carbonate is a highly reactive, moisture-sensitive coupling reagent widely used in peptide synthesis and other organic transformations. Its primary value lies in its ability to efficiently activate carboxylic acids, facilitating amide bond formation with minimal racemization, which is critical for producing high-purity peptides and complex organic molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable and high-yielding synthetic methodologies.

Application

• Activating agent for the synthesis of peptides and proteins in solid-phase and solution-phase chemistry.
• Key reagent in the preparation of amides, esters, and other carboxylic acid derivatives under mild conditions.
• Used in the synthesis of complex natural products and active pharmaceutical ingredients (APIs).
• Facilitates fragment coupling strategies in medicinal chemistry and drug discovery programs.
• Employed in bioconjugation techniques for labeling biomolecules.
• Useful in polymer chemistry for creating specialized polyamides or functionalized polymers.

Basic Information

Product Name	Bis(Hydroxybenzotriazolyl) Carbonate
CAS No.	88544-01-8
Molecular Formula	C13H8N6O5
Molecular Weight	328.24 g/mol
Synonyms	Bis(HOBt) Carbonate; HOBt Carbonate; Carbonobis(oxy)bis(1H-benzo[d][1,2,3]triazole); 1,1'-Carbonylbis(1H-benzotriazole); (1H-Benzotriazol-1-yloxy)carbonyl 1H-benzotriazolide; BBC; BHC; HOBt-Carbonate
EINECS	Contact for details

Quality Control

Our Bis(Hydroxybenzotriazolyl) Carbonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.