Description

Manassantin A is a bioactive lignan compound isolated from the Saururus chinensis plant, recognized for its potent and selective inhibitory effects on NF-κB activation. This makes it a highly valuable reference standard and research-grade biochemical for investigating inflammatory pathways and related therapeutic targets. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery and mechanistic studies.

Application

• Pharmaceutical Research: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-inflammatory and anti-cancer therapeutics.
• Biochemical Assays: Used as a selective inhibitor in cell-based and in vitro assays to study the NF-κB signaling pathway and its role in disease progression.
• Academic Research: A key tool compound for universities and research institutes investigating natural product pharmacology, inflammation biology, and signal transduction mechanisms.
• Preclinical Development: Employed in proof-of-concept and efficacy studies for candidate drugs targeting inflammatory disorders, including arthritis and metabolic diseases.
• Biotech R&D: Utilized in high-throughput screening (HTS) campaigns and target validation studies within biotechnology companies.

Basic Information

Product Name	Manassantin A
CAS No.	88497-87-4
Molecular Formula	C38H46O10
Molecular Weight	662.77 g/mol
Synonyms	Manassantin A; (1R,2S,3S,4R,5S,6S,7R,8R)-4-[(2S,3R,4S,5R,6R)-4,5-Dimethoxy-6-methyl-3-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]oxan-2-yl]oxy-2,3,5,6,7,8-hexamethoxy-1-methylnaphthalene; Saurufuran A; NF-κB inhibitor (Manassantin A)
EINECS	Contact for details

Quality Control

Our Manassantin A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized and verified using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.