Description

Acetylepipodophyllotoxin CAS NO 1180-35-4 is a semi-synthetic derivative of podophyllotoxin, a naturally occurring lignan with significant biological activity. This compound serves as a crucial intermediate in the synthesis of potent chemotherapeutic agents, most notably etoposide and teniposide. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in oncology drug development and chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of topoisomerase II inhibitors etoposide and teniposide.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of cell cycle arrest and apoptosis.
• Medicinal Chemistry: Serves as a scaffold for developing novel anti-cancer compounds and prodrugs.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and quality assurance (QA) for related APIs.
• Fine Chemical Synthesis: Utilized in custom synthesis and process development for complex organic molecules.

Basic Information

Item	Detail
Product Name	Acetylepipodophyllotoxin
CAS No.	1180-35-4
Molecular Formula	C25H24O9
Molecular Weight	468.45 g/mol
Synonyms	4'-Demethylepipodophyllotoxin 9-acetate; 4'-Demethyl-9-epipodophyllotoxin acetate; 4'-Demethyl-9-epipodophyllotoxin 9-acetate; NSC 251016; 9-Acetyl-4'-demethylepipodophyllotoxin; Epipodophyllotoxin 9-acetate, 4'-demethyl-; (5R,5aR,8aR,9S)-9-Acetyloxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8,8a,9,9a-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
EINECS	Contact for details

Quality Control

Our Acetylepipodophyllotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.