Description

Nordihydroguaiaretic Acid (CAS NO 500-38-9) is a potent natural lignan and antioxidant compound primarily derived from the creosote bush (*Larrea tridentata*). Its unique chemical structure makes it a valuable reference standard and active ingredient for research and development. This compound is essential for industries requiring high-purity, well-characterized molecules for analytical and formulation work. Key sectors include pharmaceutical research, nutraceuticals, and advanced material science.

Application

• Pharmaceutical Research & Development: Used as a reference standard in analytical methods (HPLC, LC-MS) and as a key intermediate or active pharmaceutical ingredient (API) in studies targeting inflammation and oxidative stress.
• Nutraceutical & Dietary Supplements: Serves as a potent natural antioxidant ingredient in formulations designed to support cellular health and combat free radicals.
• Cosmeceuticals: Incorporated into anti-aging and skin care products for its antioxidant properties, helping to protect skin from environmental damage.
• Food & Beverage Preservation: Acts as a natural preservative (antioxidant) to extend the shelf life of oils, fats, and other perishable food products.
• Biochemical Research: Employed as a specific inhibitor of lipoxygenase enzymes in metabolic pathway studies and biochemical assays.
• Industrial Applications: Investigated for use as a stabilizer in polymers, lubricants, and other industrial materials susceptible to oxidative degradation.

Basic Information

Product Name	Nordihydroguaiaretic Acid
CAS No.	500-38-9
Molecular Formula	C18H22O4
Molecular Weight	302.36 g/mol
Synonyms	NDGA; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane; Masoprocol; Larrea Antioxidant; Creosote Acid; Tetra-O-methyl NDGA (precursor name)
EINECS	207-903-0

Quality Control

Our Nordihydroguaiaretic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures material suitable for research, development, and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive. For long-term storage, consider sealing under an inert gas such as nitrogen or argon and maintaining temperatures at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.