Description

(R)-4-Chloro-3-Hydroxybutyric Acid Methyl Ester is a high-value chiral intermediate essential for the synthesis of optically active pharmaceuticals and fine chemicals. Its significance lies in its role as a key building block for statin drugs and other active pharmaceutical ingredients (APIs) requiring precise stereochemistry. This compound is primarily needed by research institutions, pharmaceutical development laboratories, and manufacturers of advanced chemical intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the production of cholesterol-lowering statin drugs like Atorvastatin and Rosuvastatin.
• Asymmetric Synthesis: Used as a versatile starting material or building block for the synthesis of complex, enantiomerically pure molecules.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and advanced materials where specific chirality is required.
• Biochemical Research: Serves as a precursor or standard in enzymatic studies and metabolic pathway research.
• Catalyst and Ligand Development: Utilized in the synthesis of chiral catalysts and ligands for asymmetric catalysis.

Basic Information

Product Name	(R)-4-Chloro-3-Hydroxybutyric Acid Methyl Ester
CAS No.	88496-70-2
Molecular Formula	C5H9ClO3
Molecular Weight	152.57 g/mol
Synonyms	(R)-Methyl 4-Chloro-3-hydroxybutyrate; (R)-4-Chloro-3-hydroxybutanoic Acid Methyl Ester; (3R)-4-Chloro-3-hydroxybutyric Acid Methyl Ester; Methyl (R)-(-)-4-Chloro-3-hydroxybutyrate; (R)-CHBM; (R)-HBM-C1; (R)-3-Hydroxy-4-chlorobutyric Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (R)-4-Chloro-3-Hydroxybutyric Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, GC, and NMR, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.