Description

Methyl 4-Trifluoromethylthio Benzoate is a high-value fluorinated aromatic building block, distinguished by the presence of both a trifluoromethylthio (SCF₃) and a methyl ester functional group. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after intermediate in advanced chemical synthesis. It is primarily utilized by research and development chemists and process scale-up teams within the pharmaceutical and agrochemical industries to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the SCF₃ group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals with unique electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitutions to construct complex, fluorinated aromatic systems for various R&D applications.

Basic Information

Product Name	Methyl 4-Trifluoromethylthio Benzoate
CAS No.	88489-60-5
Molecular Formula	C₉H₇F₃O₂S
Molecular Weight	236.21 g/mol
Synonyms	Methyl p-(Trifluoromethylthio)benzoate; Benzoic acid, 4-[(trifluoromethyl)thio]-, methyl ester; Methyl 4-((Trifluoromethyl)thio)benzoate; 4-(Trifluoromethylthio)benzoic acid methyl ester; Methyl 4-(Trifluoromethylsulfanyl)benzoate; SCAS-88489-60-5; Methyl 4-(trifluoromethylsulfanyl)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 4-Trifluoromethylthio Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.