Description

4-Isocyanato-Tempo is a bifunctional nitroxide radical compound that combines a stable free radical with a reactive isocyanate group. This unique structure makes it a valuable intermediate for the synthesis of spin-labeled polymers and materials, enabling the study of molecular dynamics and structure via Electron Paramagnetic Resonance (EPR) spectroscopy. It is primarily utilized by researchers and product developers in advanced polymer chemistry, materials science, and life sciences for creating functionalized surfaces, probes, and macromolecules.

Application

• Spin Labeling Agent: Covalently attaches to polymers, biomolecules, and surfaces to serve as a stable radical probe for EPR/ESR spectroscopy studies.
• Polymer Functionalization: Used as a reactive monomer or grafting agent to introduce nitroxide functionality into polyurethanes, epoxies, and other polymer backbones.
• Macromolecular Architecture: Enables the synthesis of star polymers, block copolymers, and networks via nitroxide-mediated polymerization (NMP) techniques.
• Surface Modification: Immobilizes nitroxide radicals on silica, glass, or metal oxide surfaces for sensor development and surface analysis.
• Bioconjugation: Potential use in labeling proteins, peptides, or other biomolecules for studying conformational changes and interactions.
• Antioxidant Research: Serves as a model compound or precursor in the development of novel nitroxide-based antioxidants and stabilizers.
• Magnetic Resonance Imaging (MRI) Contrast Agents: Acts as a building block for developing next-generation, targeted contrast agents.
• Advanced Material Synthesis: Key intermediate for creating smart materials, self-healing polymers, and organic radical batteries.

Basic Information

Product Name	4-Isocyanato-Tempo
CAS No.	88418-69-3
Molecular Formula	C10H17N2O3
Molecular Weight	213.26 g/mol
Synonyms	4-Isocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl; 1-Oxyl-2,2,6,6-tetramethyl-4-piperidyl isocyanate; 4-Isocyanato-TEMPO; TEMPO-4-isocyanate; 2,2,6,6-Tetramethyl-4-isocyanatopiperidin-1-oxyl; 4-Isocyanato-2,2,6,6-tetramethylpiperidinyloxy; Free Radical 2211; Proxyl isocyanate
EINECS	Contact for details

Quality Control

Our 4-Isocyanato-Tempo is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and EPR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and radical content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Radical Content (EPR)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.