Description

5-Iodo-2-((trimethylsilyl)oxy)pyrimidine is a high-value organosilicon-protected pyrimidine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling efficient, site-selective functionalization of the pyrimidine ring system, which is a core scaffold in numerous active compounds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of nucleoside analogs, antiviral agents, and novel heterocyclic libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Agrochemical Research: Used in creating new pyrimidine-based herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for functionalized pyrimidine monomers in the development of specialty polymers and organic electronic materials.
• Chemical Synthesis: Versatile reagent for cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive iodo group, facilitated by the TMS-protected hydroxyl.
• Protecting Group Strategy: The trimethylsilyl (TMS) group allows for temporary protection of the hydroxyl function, enabling multi-step synthetic sequences.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library development projects.

Basic Information

Product Name	5-Iodo-2-((trimethylsilyl)oxy)pyrimidine
CAS No.	88350-65-6
Molecular Formula	C7H11IN2OSi
Molecular Weight	294.16 g/mol
Synonyms	2-((Trimethylsilyl)oxy)-5-iodopyrimidine; 5-Iodo-2-(trimethylsiloxy)pyrimidine; 5-Iodo-2-pyrimidinol trimethylsilyl ether; 5-Iodo-2-(trimethylsilyloxy)pyrimidine; 5-Iodo-2-(O-trimethylsilyl)pyrimidinone; TMS-protected 5-iodo-2-hydroxypyrimidine; 5-Iodo-2-(trimethylsilanyloxy)pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-((trimethylsilyl)oxy)pyrimidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, supporting your quality assurance and regulatory documentation needs for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.