Description

2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is a specialized organosilicon reagent featuring a highly reactive triflate leaving group. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for introducing the 2-(trimethylsilyl)phenyl moiety.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring silicon-containing aromatic groups.
• Cross-Coupling Reactions: Serves as an effective electrophile in Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Ligand and Catalyst Synthesis: Used in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides with silicon-based functional groups.
• Material Science: A precursor in the synthesis of silicon-based polymers, dendrimers, and advanced organic electronic materials.
• Protecting Group Chemistry: The trimethylsilyl group can act as a protecting group for phenols or be utilized in directed ortho-metalation strategies.

Basic Information

Product Name	2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate
CAS No.	88284-48-4
Molecular Formula	C10H13F3O3SSi
Molecular Weight	298.36 g/mol
Synonyms	2-(Trimethylsilyl)phenyl triflate; (2-(Trimethylsilyl)phenyl) trifluoromethanesulfonate; o-(Trimethylsilyl)phenyl triflate; Trifluoromethanesulfonic acid 2-(trimethylsilyl)phenyl ester; 2-TMS-phenyl triflate
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Phenyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.