Description

Trimethylsilyl Trifluoromethanesulfonate is a highly reactive organosilicon reagent and a powerful silylating agent. Its primary value lies in its ability to introduce the trimethylsilyl (TMS) protecting group to alcohols, phenols, and carboxylic acids under mild conditions, and to act as a potent Lewis acid catalyst in organic synthesis. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precise control over reaction pathways and functional group protection is critical.

Application

• Protecting Group Chemistry: Efficient silylation of hydroxyl and carboxyl groups in complex molecule synthesis, including natural products and active pharmaceutical ingredients (APIs).
• Lewis Acid Catalyst: Facilitating Friedel-Crafts alkylations, acylations, and other carbon-carbon bond-forming reactions in fine chemical manufacturing.
• Polymerization Initiator/Catalyst: Used in the controlled cationic polymerization of vinyl ethers and other monomers for specialty polymer production.
• Reagent in Peptide Synthesis: For the protection of amino acid side chains during solid-phase peptide synthesis (SPPS).
• Derivatization Agent for GC/MS: Preparation of volatile trimethylsilyl derivatives for analytical chromatography and mass spectrometry.
• Electrolyte Additive: Research and development of components for advanced lithium-ion battery systems.

Basic Information

Product Name	Trimethylsilyl Trifluoromethanesulfonate
CAS No.	88248-68-4
Molecular Formula	C4H9F3O3SSi
Molecular Weight	222.26 g/mol
Synonyms	Trimethylsilyl Triflate; TMSOTf; (Trimethylsilyl) Trifluoromethanesulfonate; Trimethylsilyl Trifluoromethanesulphonate; Trifluoromethanesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Ester of Trifluoromethanesulfonic Acid; TMS Triflate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.