Description

2-Pyridinecarbonyl Chloride, 5-Methoxy- (9Ci) is a versatile and highly reactive acyl chloride derivative, primarily used as a key synthetic building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 5-methoxypicolinoyl moiety, a functional group of significant interest in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, especially those targeting neurological disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized picolinamide-based ligands used in asymmetric catalysis and metal complexation.
• Peptide Mimetics and Bioconjugation: Facilitates the acylation of amines in peptides or biomolecules, useful for creating probes and modifying protein function.
• Material Science Research: Employed in the synthesis of functional polymers and organic electronic materials that incorporate pyridine motifs.
• Custom Synthesis and R&D: A valuable reagent for contract research organizations (CROs) and academic labs exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 5-Methoxy- (9Ci)
CAS No.	88166-64-7
Molecular Formula	C7H6ClNO2
Molecular Weight	171.58 g/mol
Synonyms	5-Methoxypicolinoyl Chloride; 5-Methoxy-2-pyridinecarbonyl Chloride; 5-Methoxypicolinic Acid Chloride; 2-Pyridinecarbonyl chloride, 5-methoxy-; 5-Methoxy-2-picolinoyl Chloride; 5-Methoxypyridine-2-carbonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonyl Chloride, 5-Methoxy- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.