Description

5-Bromo-2-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine is a high-value, protected pyridine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for constructing complex molecular architectures where selective functionalization and stability under reaction conditions are paramount. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand Synthesis: Serves as a precursor for creating sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of organic electronic materials and liquid crystals due to its functionalized aromatic system.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille).
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) protecting group allows for the selective manipulation of other functional groups in multi-step syntheses.

Basic Information

Product Name	5-Bromo-2-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine
CAS No.	88139-92-8
Molecular Formula	C12H20BrNOSi
Molecular Weight	302.29 g/mol
Synonyms	2-((tert-Butyldimethylsilyloxy)methyl)-5-bromopyridine; 5-Bromo-2-((tert-butyldimethylsilyloxy)methyl)pyridine; 5-Bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 5-Bromo-2-(((TBDMS)oxy)methyl)pyridine; 5-Bromo-2-(hydroxymethyl)pyridine TBDMS ether; Pyridine, 5-bromo-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; TBDMS ether of 5-Bromo-2-(hydroxymethyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.