Description

n-Succinimidyl 8-Maleimidocaprylate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive maleimide group, separated by an extended 8-carbon spacer arm. This compound is critical for creating stable, site-specific conjugates between proteins, peptides, and other biomolecules, enabling advanced research and development in bioconjugation. It is an essential tool for scientists and manufacturers in the fields of antibody-drug conjugate (ADC) development, diagnostic assay manufacturing, and biopharmaceutical research, where precise and stable linkage chemistry is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing ADCs, connecting cytotoxic payloads to monoclonal antibodies via lysine residues and free thiols.
• Protein-Protein/Peptide Conjugation: Facilitates the crosslinking of different proteins or peptides to create novel bifunctional molecules for research and therapeutic applications.
• Diagnostic Reagent Preparation: Used to conjugate enzymes (e.g., HRP, alkaline phosphatase) or fluorescent dyes to antibodies and other proteins for ELISA, immunohistochemistry, and lateral flow assays.
• Surface Immobilization: Enables the covalent attachment of biomolecules to sensor chips, nanoparticles, or chromatographic resins for biosensors and affinity purification.
• Polymer Modification: Functionalizes polymers with maleimide groups for subsequent conjugation with thiol-containing ligands or drugs.
• Biomaterial Engineering: Incorporates into hydrogels or scaffolds to create bioactive materials with controlled cell-adhesion properties.

Basic Information

Product Name	n-Succinimidyl 8-Maleimidocaprylate
CAS No.	87981-03-1
Molecular Formula	C17H22N2O7
Molecular Weight	366.37 g/mol
Synonyms	8-Maleimidocaprylic Acid N-Succinimidyl Ester; SMCC (8-atom spacer analog); NHS-PEG8-Maleimide (approximate); N-Succinimidyl 8-Maleimidooctanoate; Maleimidocaproyl-N-hydroxysuccinimide ester (C8); ε-Maleimidocaprylic Acid N-Hydroxysuccinimide Ester; 8-(Maleimidocapryloyloxy)succinimide; N-(ε-Maleimidocaproyloxy)succinimide (C8 version)
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 8-Maleimidocaprylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for reproducible bioconjugation results. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional suitability. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in DMF, DMSO, acetonitrile
Water Content (KF)	≤ 1.0%
Functional Test	Conjugation efficiency ≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.