Description

Methyl (E)-3-[6-[1-Hydroxy-1-(4-Methylphenyl)-3-(1-Pyrrolidinyl)Propyl]-2-Pyridyl]Acrylate is a high-purity, non-racemic chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, structurally complex building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical purity. Pharmaceutical R&D departments and fine chemical manufacturers need this advanced intermediate for constructing sophisticated molecular architectures in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to introduce defined stereocenters into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its unique pyrrolidinyl and pyridyl motifs.
• Process Chemistry Development: Acts as a starting material or intermediate in the scale-up and route scouting for new API manufacturing processes.
• Fine Chemical Production: Utilized in the contract manufacturing of high-value specialty chemicals for the life sciences industry.

Basic Information

Product Name	Methyl (E)-3-[6-[1-Hydroxy-1-(4-Methylphenyl)-3-(1-Pyrrolidinyl)Propyl]-2-Pyridyl]Acrylate
CAS No.	87849-05-6
Molecular Formula	C24H30N2O3
Molecular Weight	394.51 g/mol
Synonyms	Methyl (2E)-3-[6-[1-Hydroxy-1-(4-methylphenyl)-3-pyrrolidin-1-ylpropyl]pyridin-2-yl]prop-2-enoate; (E)-Methyl 3-(6-(1-hydroxy-1-(p-tolyl)-3-(pyrrolidin-1-yl)propyl)pyridin-2-yl)acrylate; 87849-05-6; Methyl 3-[6-[1-Hydroxy-1-(4-methylphenyl)-3-(1-pyrrolidinyl)propyl]-2-pyridinyl]-2-propenoate, (E)-; 2-Propenoic acid, 3-[6-[1-hydroxy-1-(4-methylphenyl)-3-(1-pyrrolidinyl)propyl]-2-pyridinyl]-, methyl ester, (E)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request. Our quality management system supports development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.