Description

5-(2-Trifluoromethoxyphenyl)-Picolinic Acid is a high-value, multi-functional organic building block featuring a picolinic acid core substituted with a trifluoromethoxy phenyl group. This compound matters for its unique structural motif, which combines the metal-chelating properties of picolinic acid with the enhanced lipophilicity, metabolic stability, and electronic effects imparted by the trifluoromethoxy substituent. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly as a key intermediate in synthesizing complex molecules for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), especially in developing kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Ligand in Catalysis: Serves as a precursor for creating specialized picolinic acid-derived ligands used in transition metal catalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) due to its rigid, aromatic structure and coordinating ability.
• Chemical Biology Probes: Utilized as a core structure for designing fluorescent probes or chelating agents for studying biological metal ion transport and signaling.

Basic Information

Product Name	5-(2-Trifluoromethoxyphenyl)-Picolinic Acid
CAS No.	87789-69-3
Molecular Formula	C14H8F3NO3
Molecular Weight	295.21 g/mol
Synonyms	5-[2-(Trifluoromethoxy)phenyl]pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-[2-(trifluoromethoxy)phenyl]-; 5-(2-(Trifluoromethoxy)phenyl)picolinic acid; 5-(α,α,α-Trifluoro-o-tolyloxy)picolinic acid; Picolinic acid, 5-(2-trifluoromethoxyphenyl)-; 5-(2-Trifluoromethoxy-phenyl)-pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(2-Trifluoromethoxyphenyl)-Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.