Description

1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone is a high-value organosilicon-protected trifluoromethyl ketone intermediate. This compound is critical for its role in advanced organic synthesis, particularly in the preparation of complex molecules where selective protection and the introduction of fluorine-containing groups are required. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those incorporating trifluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the fluorine atom's ability to modulate biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic electronic materials where silicon and fluorine functionalities are desired.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes as a protected carbonyl compound, enabling complex molecular constructions in academic and industrial settings.
• Fluorine Chemistry: An essential reagent for exploring new methodologies in fluoroorganic chemistry and creating compounds with unique physicochemical properties.

Basic Information

Product Name	1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone
CAS No.	87736-75-2
Molecular Formula	C15H21F3O2Si
Molecular Weight	318.41 g/mol
Synonyms	1-[4-[[(tert-Butyldimethylsilyl)oxy]methyl]phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]ethanone; 4-((tert-Butyldimethylsilyloxy)methyl)phenacyl trifluoride; TBDMS-protected 4-(Trifluoroacetyl)benzyl alcohol; 4-(Trifluoroacetyl)benzyl tert-butyldimethylsilyl ether; 87736-75-2; TBDMS ether of 4-(Trifluoroacetyl)benzyl alcohol
EINECS	Contact for details

Quality Control

Our production of 1-[4-[[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenyl]-2,2,2-Trifluoro-Ethanone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.