Description

(4-Bromophenyl)Methoxy-tert-Butyl-Dimethylsilane is a high-purity organosilicon reagent featuring a bromophenyl group protected by a robust tert-butyldimethylsilyl (TBDMS) ether. This compound is a critical building block in advanced organic synthesis, offering a stable, protected phenolic intermediate that facilitates complex multi-step reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key protected phenolic precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromophenyl moiety is a core structural element.
• Liquid Crystal & OLED Material Production: Acts as a synthon for creating advanced organic electronic materials, including charge-transport layers and emissive compounds.
• Polymer & Resin Modification: Employed to introduce brominated aromatic functionality into specialty polymers, enhancing flame retardancy or enabling further cross-linking.
• Cross-Coupling Reactions: The aryl bromide group is an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Protecting Group Strategy: The TBDMS ether provides a stable protecting group for the phenol, allowing selective manipulation of other functional groups in complex molecule synthesis.

Basic Information

Product Name	(4-Bromophenyl)Methoxy-tert-Butyl-Dimethylsilane
CAS No.	87736-74-1
Molecular Formula	C13H21BrOSi
Molecular Weight	301.30 g/mol
Synonyms	4-Bromophenoxy-tert-butyldimethylsilane; 1-Bromo-4-[(tert-butyldimethylsilyl)oxy]benzene; tert-Butyl(4-bromophenoxy)dimethylsilane; p-Bromophenoxy-tert-butyldimethylsilane; TBDMS ether of 4-bromophenol; Silane, (4-bromophenoxy)(1,1-dimethylethyl)dimethyl-; 4-Bromophenyl tert-butyldimethylsilyl ether; 4-BrC6H4OTBDMS
EINECS	Contact for details

Quality Control

Every batch of (4-Bromophenyl)Methoxy-tert-Butyl-Dimethylsilane is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.