Description

Silane, (1,1-Dimethylethyl)Dimethyl[[(3β,5E,7E)-9,10-Secocholesta-5,7,10(19)-Trien-3-Yl]Oxy]- is a specialized organosilane derivative of vitamin D, designed for advanced chemical synthesis and pharmaceutical research. This compound is critical for introducing silyl-protecting groups in complex organic and medicinal chemistry, enabling precise control over molecular structure and reactivity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel therapeutic agents and high-value intermediates. Its unique structure makes it an essential reagent for targeted modifications in steroidal and secosteroidal frameworks.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for the development of vitamin D analogs and other secosteroid-based active pharmaceutical ingredients (APIs).
• Protecting Group Chemistry: Used as a silylating agent to protect hydroxyl groups during multi-step synthetic sequences, particularly in sensitive steroidal molecules.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by facilitating specific functionalization of the vitamin D core structure.
• Process Chemistry Development: Employed in scaling up synthetic routes for novel therapeutic candidates under GMP-like conditions.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled or tagged compounds for biological testing and diagnostic applications.
• Fine Chemical Manufacturing: Used in the production of high-purity, custom-synthesized chemicals for research and development contracts.

Basic Information

Product Name	Silane, (1,1-Dimethylethyl)Dimethyl[[(3β,5E,7E)-9,10-Secocholesta-5,7,10(19)-Trien-3-Yl]Oxy]-
CAS No.	87649-55-6
Molecular Formula	C33H58OSi
Molecular Weight	498.90 g/mol
Synonyms	tert-Butyldimethyl((3β,5E,7E)-9,10-secocholesta-5,7,10(19)-trien-3-yloxy)silane; TBDMS Ether of Vitamin D3; (3β,5E,7E)-3-[(tert-Butyldimethylsilyl)oxy]-9,10-secocholesta-5,7,10(19)-triene; Vitamin D3 tert-Butyldimethylsilyl Ether; Cholecalciferol TBDMS ether; 3β-[(tert-Butyldimethylsilyl)oxy]cholesta-5,7,10(19)-triene
EINECS	Contact for details

Quality Control

Every batch of our Silane, (1,1-Dimethylethyl)Dimethyl[[(3β,5E,7E)-9,10-Secocholesta-5,7,10(19)-Trien-3-Yl]Oxy]- is manufactured and tested under strict quality management systems to ensure high purity and batch-to-batch consistency essential for research and development. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D and fine chemical synthesis. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress, which can compromise product stability and reactivity. For long-term storage, consider using desiccants or storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.