Description

1-(Triisopropylsilyl)Pyrrole is a specialized organosilicon compound featuring a pyrrole ring protected by a bulky triisopropylsilyl (TIPS) group. This protection is critical for its role as a key synthetic intermediate and protecting group in advanced organic synthesis, particularly for pharmaceuticals and agrochemicals. It is primarily utilized by research chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries to enable complex multi-step reactions with high selectivity and yield.

Application

• Pharmaceutical Intermediate: Serves as a protected pyrrole building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing indole or complex heterocyclic systems.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the pyrrole moiety is a core structural component.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the creation of conductive polymers, organic semiconductors, and advanced organic frameworks.
• Organic Synthesis Reagent: Functions as a versatile reagent for introducing the pyrrole nucleus into complex molecules under mild conditions, leveraging the TIPS group for temporary protection.
• Research & Development: Essential in academic and industrial R&D labs for methodology development and exploring new chemical spaces in medicinal chemistry.
• Fine Chemical Production: Employed in the custom synthesis of high-value, low-volume specialty chemicals for various technological applications.

Basic Information

Product Name	1-(Triisopropylsilyl)Pyrrole
CAS No.	87630-35-1
Molecular Formula	C13H25NSi
Molecular Weight	223.43 g/mol
Synonyms	1-(Triisopropylsilyl)-1H-pyrrole; N-(Triisopropylsilyl)pyrrole; Pyrrole, 1-(triisopropylsilyl)-; TIPS-Pyrrole; 1H-Pyrrole, 1-(triisopropylsilyl)-; 1-Triisopropylsilylpyrrole; N-Triisopropylsilylpyrrole
EINECS	Contact for details

Quality Control

Our 1-(Triisopropylsilyl)Pyrrole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.