Description

3-[2-(tert-Butyl-Diphenyl-Silanyloxy)-Ethyl]-3,4-Dihydro-2H-Pyran-4-Ol is a high-value, protected dihydropyranol derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its core value lies in enabling the stereoselective construction of complex molecular architectures, particularly in the synthesis of pharmaceuticals and fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a versatile chiral auxiliary or precursor in asymmetric synthesis to introduce stereogenic centers with high enantiomeric excess.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products and bioactive molecules, leveraging its functionalized pyran ring.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Material Science Precursor: Used in the research and development of advanced organic materials, such as liquid crystals or functional polymers, where its siloxy-protected group offers further derivatization potential.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production of target molecules in process chemistry laboratories.

Basic Information

Product Name	3-[2-(tert-Butyl-Diphenyl-Silanyloxy)-Ethyl]-3,4-Dihydro-2H-Pyran-4-Ol
CAS No.	87614-59-3
Molecular Formula	C23H30O3Si
Molecular Weight	382.57 g/mol
Synonyms	3-[2-[(1,1-Dimethylethyl)diphenylsilyl]oxy]ethyl]-3,4-dihydro-2H-pyran-4-ol; 3,4-Dihydro-3-[2-[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-2H-pyran-4-ol; 3-[2-(tert-Butyldiphenylsilyloxy)ethyl]-3,4-dihydro-2H-pyran-4-ol; TBDPS-protected dihydropyranol; (4-Hydroxy-3,4-dihydro-2H-pyran-3-yl)ethyl tert-butyldiphenylsilyl ether; 87614-59-3; tert-Butyl[2-(4-hydroxy-3,4-dihydro-2H-pyran-3-yl)ethoxy]diphenylsilane
EINECS	Contact for details

Quality Control

Our 3-[2-(tert-Butyl-Diphenyl-Silanyloxy)-Ethyl]-3,4-Dihydro-2H-Pyran-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, IR, MS) to ensure structural integrity and batch-to-batch consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.