Description

4-(Diethylphosphono)-3-Methyl-2-Butenenitrile, E/Z Mixture is a versatile organophosphorus building block featuring a reactive nitrile group and a phosphonate moiety. This compound is critical for the synthesis of complex molecules, particularly in the development of pharmaceuticals and advanced agrochemicals. It serves as a key intermediate for researchers and manufacturers in fine chemical, pharmaceutical, and crop protection industries requiring high-purity synthetic precursors.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing phosphorus or requiring specific stereochemistry.
• Agrochemical Synthesis: Serves as a crucial precursor for developing novel insecticides, herbicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphonate-based ligands for metal-catalyzed reactions.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced polymers and functional materials.
• Organic Synthesis Building Block: Utilized in Horner-Wadsworth-Emmons (HWE) olefination reactions to construct complex alkene frameworks.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological pathways and enzyme inhibition.

Basic Information

Product Name	4-(Diethylphosphono)-3-Methyl-2-Butenenitrile, E/Z Mixture
CAS No.	87549-50-6
Molecular Formula	C9H16NO3P
Molecular Weight	217.20 g/mol
Synonyms	Diethyl (1-Cyano-2-methylprop-1-en-1-yl)phosphonate; 3-Methyl-2-butenenitrile, 4-(diethylphosphono)-; (1-Cyano-2-methylprop-1-enyl)phosphonic Acid Diethyl Ester; Diethyl (1-Cyano-2-methyl-1-propenyl)phosphonate; 4-(Diethoxyphosphoryl)-3-methylbut-2-enenitrile; E/Z Mixture of 4-(Diethylphosphono)-3-methyl-2-butenenitrile
EINECS	Contact for details

Quality Control

Our 4-(Diethylphosphono)-3-Methyl-2-Butenenitrile, E/Z Mixture is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen to prevent degradation. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (E/Z Mixture)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.