Description

1,25-Dihydroxy-23-Thiavitamin D3 is a synthetic analog of the biologically active form of vitamin D, featuring a sulfur-for-carbon substitution at the 23-position. This structural modification is designed to enhance metabolic stability and modulate receptor binding affinity for research into calcium homeostasis and cell differentiation. It serves as a critical reference standard and research chemical for pharmaceutical development and biochemical studies. Key users include R&D laboratories in the pharmaceutical, biotechnology, and academic sectors focused on endocrinology, oncology, and metabolic disease research.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of vitamin D analogs in method development, validation, and quality control.
• Biochemical Research: A vital tool for studying the Vitamin D receptor (VDR) pathway, its activation mechanisms, and downstream gene expression.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of novel therapeutics targeting osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Investigates the role of vitamin D analogs in calcium and phosphate homeostasis, both in vitro and in vivo.
• Academic Research: Utilized in university and institutional labs for fundamental research in endocrinology and cell biology.

Basic Information

Product Name	1,25-Dihydroxy-23-Thiavitamin D3
CAS No.	87480-00-0
Molecular Formula	C₂₇H₄₄O₃S
Molecular Weight	448.71 g/mol
Synonyms	23-Thia-1,25-dihydroxyvitamin D3; 1,25-Dihydroxy-23-thiacholecalciferol; 23-Thia-1α,25-dihydroxyvitamin D3; 1α,25-Dihydroxy-23-thiavitamin D3; Calcitriol 23-thia analog; 23-Thiacalcitriol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,23-trithiol-25-ol
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-23-Thiavitamin D3 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, MS). We provide a Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.