Description

24-Fluoro-1,25-Dihydroxyvitamin D2 is a fluorinated analog of the active form of vitamin D2, designed to modulate biological activity and metabolic stability. This compound is of significant interest for advanced research into vitamin D receptor (VDR) signaling pathways and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on endocrinology, oncology, and metabolic disease studies.

Application

• Pharmaceutical Research & Development: A key reference standard and synthetic intermediate for developing new vitamin D receptor (VDR) modulators and analogs.
• Biochemical Research: Used in in vitro and in vivo studies to investigate the structure-activity relationship (SAR) of fluorinated vitamin D compounds on cell differentiation and proliferation.
• Metabolic Pathway Studies: Employed as a molecular tool to study calcium and phosphate homeostasis, as well as immune system modulation.
• Fine Chemical Synthesis: Serves as a high-value building block for the custom synthesis of specialized vitamin D derivatives for clinical research.
• Reference Standard Manufacturing: Supplied to analytical laboratories and quality control departments for method development and compound verification.

Basic Information

Product Name	24-Fluoro-1,25-Dihydroxyvitamin D2
CAS No.	135776-86-2
Molecular Formula	C₂₈H₄₃FO₃
Molecular Weight	446.64 g/mol
Synonyms	24-Fluoro-1,25-dihydroxyergocalciferol; 24-Fluoro-1α,25-dihydroxyvitamin D₂; 24-Fluoro-1,25-(OH)₂D₂; 24-Fluoro-1,25-dihydroxyvitamin D2; Falecalcitriol analog; 24-Fluorocalcitriol analog; 24-Fluoro-1α,25-dihydroxyergocalciferol
EINECS	Contact for details

Quality Control

Our 24-Fluoro-1,25-Dihydroxyvitamin D2 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.