Description

22-(3-(Dimethylhydroxymethyl)Phenyl)-23,24,25,26,27-Pentanor-1-Hydroxyvitamin D3 is a synthetic, biologically active vitamin D analog. This compound is significant for its role as a key intermediate in the research and development of novel vitamin D receptor modulators and active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in metabolic bone disease research, cancer studies, and the synthesis of next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced vitamin D analogs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and probe in studies of vitamin D receptor (VDR) binding and activation mechanisms.
• Drug Discovery: Serves as a precursor in the development of new therapeutics for osteoporosis, psoriasis, and certain cancers.
• Fine Chemical Synthesis: Employed in custom synthesis and process development for high-value, low-volume specialty chemicals.
• Metabolic Studies: Utilized in research investigating calcium homeostasis and bone metabolism pathways.

Basic Information

Product Name	22-(3-(Dimethylhydroxymethyl)Phenyl)-23,24,25,26,27-Pentanor-1-Hydroxyvitamin D3
CAS No.	133910-11-9
Molecular Formula	C30H44O2
Molecular Weight	436.67 g/mol
Synonyms	1α-Hydroxy-22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanorvitamin D3; 22-(3-(Hydroxydimethylmethyl)phenyl)-23,24,25,26,27-pentanor-1α-hydroxyvitamin D3; Vitamin D3 analog; 1α-OH-D3 analog; Secosteroid intermediate; Calcitriol analog precursor
EINECS	Contact for details

Quality Control

Our 22-(3-(Dimethylhydroxymethyl)Phenyl)-23,24,25,26,27-Pentanor-1-Hydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or Certificate of Analysis. For long-term storage, consider storage under an inert atmosphere at -20°C. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Residues (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.