Description

(2E,7R,11S)-Vitamin K1 is a specific, high-purity stereoisomer of phytonadione, a fat-soluble vitamin essential for blood coagulation and bone metabolism. This defined stereochemistry is critical for ensuring optimal biological activity and consistency in advanced pharmaceutical formulations. It is primarily required by manufacturers in the pharmaceutical and nutraceutical industries for producing standardized injectable solutions, oral supplements, and research-grade biochemicals where precise molecular structure directly impacts efficacy and regulatory compliance.

Application

• Pharmaceutical Active Ingredient: Core component in the manufacture of injectable vitamin K1 solutions for the treatment of coagulation disorders and anticoagulant overdose.
• Nutraceutical Formulations: Used in high-end dietary supplements and vitamin complexes targeting bone health and cardiovascular support.
• Biochemical Research: Essential standard and reagent in metabolic studies, enzymology research related to the vitamin K cycle, and clinical diagnostics.
• Cell Culture Media: Added as a defined growth factor in specialized serum-free media for certain cell lines.
• Veterinary Pharmaceuticals: Incorporated into animal health products for treating vitamin K deficiency and related bleeding disorders.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in regulatory and quality assurance laboratories.

Basic Information

Product Name	(2E,7R,11S)-Vitamin K1
CAS No.	132487-93-5
Molecular Formula	C₃₁H₄₆O₂
Molecular Weight	450.70 g/mol
Synonyms	Phytonadione; Phylloquinone; Phytomenadione; Vitamin K1; 2-Methyl-3-phytyl-1,4-naphthoquinone; (2E,7R,11R)-Phytonadione; Konakion; AquaMEPHYTON; Mephyton; 3-Phytylmenadione
EINECS	Contact for details

Quality Control

Our (2E,7R,11S)-Vitamin K1 is manufactured under strict quality systems to meet the exacting standards of the pharmaceutical industry. Each batch is tested to ensure compliance with relevant pharmacopoeial monographs (e.g., USP, EP) for identity, purity, potency, and stereochemical composition. Comprehensive Certificates of Analysis (COA) documenting all test results, including chiral purity by HPLC, are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at controlled room temperature (15-25°C) or as specified. This product is easily oxidized and light-sensitive; prolonged exposure to air, light, or heat should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange, clear, viscous oil
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Chiral Purity (Stereoisomeric Content)	≥ 98.0% (2E,7R,11S)-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.