Description

(2E,7S,11R)-Vitamin K1 is a specific, high-purity stereoisomer of phytonadione, a fat-soluble vitamin essential for blood coagulation and bone metabolism. This compound matters for its superior biological activity and consistency, which is critical for precise formulation in pharmaceutical and nutraceutical applications. It is primarily needed by manufacturers of injectable pharmaceuticals, advanced dietary supplements, and clinical research materials where stereochemical purity directly impacts efficacy and safety.

Application

• Pharmaceutical Active Ingredient: Primary use in the formulation of injectable vitamin K1 solutions for the treatment of coagulation disorders and as an antidote for certain anticoagulant overdoses.
• Nutraceutical & Dietary Supplements: A key ingredient in high-end bone health and cardiovascular support supplements, valued for its defined stereochemistry and bioavailability.
• Clinical & Biomedical Research: Used as a reference standard in analytical laboratories and for studying the role of vitamin K in biochemistry, including its function in the γ-carboxylation of glutamate residues in proteins.
• Cell Culture & Microbiology: Employed in specialized growth media formulations that require the addition of vitamin K for specific metabolic pathways.
• Veterinary Medicine: Incorporated into formulations for treating vitamin K deficiency and related bleeding disorders in animals.

Basic Information

Product Name	(2E,7S,11R)-Vitamin K1
CAS No.	132487-95-7
Molecular Formula	C₃₁H₄₆O₂
Molecular Weight	450.70 g/mol
Synonyms	Phytonadione (stereospecific); (2E,7S,11R)-Phylloquinone; Vitamin K1 (all-trans); 2-Methyl-3-[(2E,7S,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthoquinone; Konakion; Phytomenadione; Phylloquinone; (2E,7S,11R)-2-Methyl-3-phytyl-1,4-naphthoquinone
EINECS	Contact for details

Quality Control

Our (2E,7S,11R)-Vitamin K1 is manufactured under strict quality systems. Each batch is tested to meet high-purity standards, with specifications aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, stereochemical composition, and impurity profiles is provided with every shipment to ensure full traceability and compliance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature (15-25°C) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange, clear, viscous oil
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Stereoisomeric Purity (HPLC)	≥ 99.0% (2E,7S,11R)-isomer
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.1%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.