Description

22-Fluorovitamin D3 is a fluorinated analog of the essential secosteroid hormone, Vitamin D3 (Cholecalciferol). This compound is of significant interest in pharmaceutical research and development due to the strategic introduction of fluorine, which can enhance metabolic stability and modulate biological activity. It serves as a critical intermediate and reference standard for scientists in the life sciences sector, particularly those developing novel therapeutics targeting vitamin D receptor pathways, metabolic disorders, and bone health.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel vitamin D analogs and prodrugs with potential therapeutic applications.
• Biochemical Research: Used as a reference standard and probe in studies investigating the structure-activity relationship (SAR) of vitamin D receptor (VDR) ligands.
• Metabolic Studies: Employed in research to understand the impact of fluorination on the metabolism, pharmacokinetics, and biological half-life of vitamin D compounds.
• Academic & Institutional R&D: Essential reagent for universities and research institutes exploring endocrinology, calcium homeostasis, and related biological pathways.
• High-Purity Reference Material: Sourced by analytical laboratories and manufacturers for method development, calibration, and quality control of related pharmaceutical products.

Basic Information

Product Name	22-Fluorovitamin D3
CAS No.	110536-31-7
Molecular Formula	C₂₇H₄₃FO
Molecular Weight	402.63 g/mol
Synonyms	22-Fluoro-9,10-secocholesta-5,7,10(19)-trien-3β-ol; 22-Fluorocholecalciferol; 22-Fluoro Vitamin D3; 22-F-D3; (3β,5Z,7E)-22-Fluoro-9,10-secocholesta-5,7,10(19)-trien-3-ol; 22-Fluorocalciol; 22-Fluorovitamin D₃
EINECS	Contact for details

Quality Control

Our 22-Fluorovitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity, well-characterized biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the CoA. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.