Description

(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol is a sophisticated, high-purity synthetic intermediate characterized by its complex stereochemistry and functional groups. This compound is critical for enabling precise molecular construction in advanced pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly in steroid and terpenoid-related therapeutic areas.
• Advanced Organic Synthesis: Used in research laboratories for constructing complex molecular architectures, leveraging its protected hydroxyl and olefin functionalities for further selective transformations.
• Process Chemistry Development: Serves as a critical reference standard or starting material for scaling up synthetic routes from milligram to kilogram scale under Good Manufacturing Practice (GMP) conditions.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile scaffold for the introduction of various pharmacophores.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions due to its defined stereocenters, aiding in the production of enantiomerically pure compounds.

Basic Information

Item	Details
Product Name	(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol
CAS No.	87407-51-0
Molecular Formula	C28H48O2Si
Molecular Weight	444.78 g/mol
Synonyms	1-Propanol, 2-[(1R,3aS,7aR,E)-4-[(1E)-2-[(1S)-5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-methylene-1-cyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]-, (2S)-; (S)-TBDMS Protected Steroid Intermediate; (2S)-2-[(1R,3aS,7aR,E)-4-[(E)-2-[(1S)-5-[(tert-Butyldimethylsilyl)oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propan-1-ol; Steroid Synthesis Intermediate CAS 87407-51-0; TBS-protected Diene Alcohol
EINECS	Contact for details

Quality Control

Our (S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is sensitive to fluoride ions and strong alkali; ensure it is stored separately from such materials. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.