Description

1-[3-(Trifluoromethyl)Pyrid-2-Yl]Piperazine is a high-value, nitrogen-containing heterocyclic compound featuring a piperazine ring linked to a trifluoromethyl-substituted pyridine moiety. This structure is critical for its role as a versatile and potent building block in modern pharmaceutical and agrochemical research and development. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, where it serves as a key intermediate for synthesizing novel active ingredients. The compound's unique combination of a basic piperazine and an electron-deficient pyridine ring makes it invaluable for creating molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for enhanced bioactivity and stability.
• Ligand in Catalysis: Serves as a precursor for nitrogen-donor ligands used in transition metal-catalyzed reactions.
• Material Science Research: Investigated as a monomer or functional component in the creation of specialty polymers and advanced organic materials.
• Chemical Biology Probe Development: Utilized to create molecular tools for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Pyrid-2-Yl]Piperazine
CAS No.	87394-63-6
Molecular Formula	C10H12F3N3
Molecular Weight	231.22 g/mol
Synonyms	2-(1-Piperazinyl)-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-piperazin-1-ylpyridine; 1-[3-(Trifluoromethyl)-2-pyridyl]piperazine; 2-Piperazinyl-3-trifluoromethylpyridine; 3-Trifluoromethyl-2-piperazinopyridine; 1-(3-Trifluoromethylpyridin-2-yl)piperazine; 87394-63-6 (CAS Name)
EINECS	Contact for details

Quality Control

Our 1-[3-(Trifluoromethyl)Pyrid-2-Yl]Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For cGMP-grade material or material manufactured under specific pharmacopeial standards (e.g., USP/EP), please contact our technical sales team for availability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.