Description

2-(Piperazin-1-Yl)Nicotinonitrile Bihydrochloride is a high-purity, versatile chemical intermediate with significant utility in advanced organic synthesis. Its core value lies in its functionalized pyridine and piperazine rings, which serve as key building blocks for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology & Proteomics: Serves as a scaffold or linker in the design of molecular probes and enzyme inhibitors for biochemical research.
• Material Science: Employed in the synthesis of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	2-(Piperazin-1-Yl)Nicotinonitrile Bihydrochloride
CAS No.	87394-51-2
Molecular Formula	C10H13N5 · 2HCl
Molecular Weight	284.17 g/mol (as free base: 203.25 g/mol)
Synonyms	2-(1-Piperazinyl)nicotinonitrile dihydrochloride; 2-Piperazin-1-ylnicotinonitrile dihydrochloride; Nicotinonitrile, 2-(1-piperazinyl)-, dihydrochloride; 2-(Piperazin-1-yl)pyridine-3-carbonitrile dihydrochloride; 3-Cyano-2-(piperazin-1-yl)pyridine dihydrochloride; 87394-51-2 (CAS); 2-Piperazinyl-3-cyanopyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)Nicotinonitrile Bihydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Related Substances (HPLC)	Single impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.