Description

4-(tert-Butyldimethylsilyloxy)Butanal is a versatile organosilicon-protected aldehyde intermediate of significant importance in synthetic organic chemistry. Its core value lies in its role as a key building block for the controlled introduction of the 4-hydroxybutanal moiety in complex molecule synthesis. This compound is primarily needed by research and development chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs), natural products, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly where a protected hydroxyl-aldehyde functionality is required.
• Peptide & Nucleotide Synthesis: Used in the preparation of modified amino acids or nucleoside analogs, where the silyl protecting group offers orthogonal protection strategies.
• Natural Product Synthesis: Serves as a key chiral synthon or fragment in the total synthesis of complex natural products with bioactive properties.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that require specific aldehyde intermediates for coupling reactions.
• Polymer & Material Science: Acts as a monomer or cross-linking agent precursor for synthesizing specialty polymers, dendrimers, or functionalized surfaces with tailored properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes, leveraging its reactive aldehyde group for bioconjugation.

Basic Information

Product Name	4-(tert-Butyldimethylsilyloxy)Butanal
CAS No.	87184-81-4
Molecular Formula	C10H22O2Si
Molecular Weight	202.37 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]butanal; 4-(TBDMSO)Butanal; 4-(tert-Butyldimethylsiloxy)butyraldehyde; 4-Hydroxybutanal TBDMS ether; 4-Oxo-butyloxy-tert-butyldimethylsilane; Butanal, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; TBDMS-protected 4-hydroxybutanal; γ-(tert-Butyldimethylsilyloxy)butyraldehyde
EINECS	Contact for details

Quality Control

Our 4-(tert-Butyldimethylsilyloxy)Butanal is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.