Description

Methyl 2,2-Difluorobutanoate is a specialized fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoroalkyl group, enabling the introduction of fluorine atoms to modulate the physical, chemical, and biological properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and prodrugs, where fluorine substitution can enhance metabolic stability, bioavailability, and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, leveraging fluorine to improve efficacy, environmental persistence, and selectivity.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and coatings with tailored surface properties, such as oil and water repellency (fluoropolymers).
• Organic Synthesis Reagent: Employed in nucleophilic substitution and cross-coupling reactions to introduce the -CH(CF2)CO2Me moiety into complex molecular architectures.
• Liquid Crystal & Electronic Chemicals: Potential intermediate for fluorinated liquid crystal materials and dielectric fluids used in advanced display and electronics manufacturing.

Basic Information

Product Name	Methyl 2,2-Difluorobutanoate
CAS No.	86966-96-3
Molecular Formula	C5H8F2O2
Molecular Weight	138.11 g/mol
Synonyms	2,2-Difluorobutanoic Acid Methyl Ester; Methyl 2,2-Difluorobutyrate; Butanoic acid, 2,2-difluoro-, methyl ester; Methyl α,α-Difluorobutyrate
EINECS	Contact for details

Quality Control

Our Methyl 2,2-Difluorobutanoate is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.