Description

n-Boc-2-Hydroxypiperidine is a versatile and high-purity Boc-protected piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a protected amine and alcohol functionality, enabling precise and efficient multi-step reactions without unwanted side interactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), complex natural products, and novel fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including potential antiviral, anticancer, and central nervous system (CNS) agents.
• Peptidomimetics & PROTACs: Used in constructing peptide backbones and linkers for Proteolysis Targeting Chimeras (PROTACs) due to its orthogonal protecting groups.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and catalysts used in enantioselective synthesis.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	n-Boc-2-Hydroxypiperidine
CAS No.	86953-81-3
Molecular Formula	C₁₀H₁₉NO₃
Molecular Weight	201.26 g/mol
Synonyms	2-Hydroxy-1-(tert-butoxycarbonyl)piperidine; tert-Butyl 2-hydroxypiperidine-1-carboxylate; 1-Boc-2-hydroxypiperidine; 1-N-Boc-2-piperidinol; 2-Hydroxy-N-Boc-piperidine; 1-(tert-Butoxycarbonyl)-2-piperidinol; 2-Piperidinol, 1-[(1,1-dimethylethoxy)carbonyl]-; N-Boc-2-piperidinol
EINECS	Contact for details

Quality Control

Our n-Boc-2-Hydroxypiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by techniques such as HPLC, GC, NMR, and IR spectroscopy. We adhere to cGMP principles where applicable, and our quality systems support regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.