Description

(2-Bromoethoxy)-tert-butyldimethylsilane is a versatile organosilicon reagent featuring a bromoethyl group protected by a tert-butyldimethylsilyl (TBDMS) ether. This bifunctional molecule is critical for introducing protected hydroxylalkyl linkers in complex organic syntheses, offering a stable handle for further functionalization. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing key intermediates in drug discovery and specialty polymer development.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the preparation of prodrugs, linker molecules in antibody-drug conjugates (ADCs), and other bioactive compounds requiring a protected hydroxyl functionality.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent in the synthesis of specialty silicones, dendrimers, and surface-modified materials.
• Organic Synthesis Reagent: Used as a protected 2-bromoethanol equivalent in nucleophilic substitution reactions, enabling the elongation of carbon chains with a latent alcohol group.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that incorporate siloxane or alkoxy-silane motifs.
• Peptide & Carbohydrate Chemistry: Facilitates the selective protection of hydroxyl groups during the multi-step synthesis of complex natural products and glycoconjugates.

Basic Information

Product Name	(2-Bromoethoxy)-tert-butyldimethylsilane
CAS No.	86864-60-0
Molecular Formula	C8H19BrOSi
Molecular Weight	239.23 g/mol
Synonyms	2-Bromoethoxy-tert-butyldimethylsilane; tert-Butyl(2-bromoethoxy)dimethylsilane; 2-(tert-Butyldimethylsilyloxy)ethyl Bromide; 2-Bromoethyl tert-Butyldimethylsilyl Ether; TBDMS-2-bromoethyl ether; (2-Bromoethyloxy)-tert-butyldimethylsilane; Silane, (2-bromoethoxy)-1,1-dimethylethyl)dimethyl-; 1-Bromo-2-[(tert-butyldimethylsilyl)oxy]ethane
EINECS	Contact for details

Quality Control

Our (2-Bromoethoxy)-tert-butyldimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.