Description

Dihydromonacolin L is a key intermediate in the biosynthesis of cholesterol-lowering statin drugs. This compound matters as a critical building block for pharmaceutical research and development, particularly in the synthesis of more complex monacolin derivatives. It is primarily needed by manufacturers and R&D teams in the pharmaceutical, nutraceutical, and fine chemical industries for producing active pharmaceutical ingredients (APIs) and conducting metabolic pathway studies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthetic pathways for statin-class drugs like Lovastatin and Simvastatin.
• Biochemical Research: Used as a standard or substrate in studies investigating the HMG-CoA reductase enzyme and cholesterol biosynthesis.
• Nutraceutical Development: Serves as a reference compound in the quality control and standardization of red yeast rice extracts and related supplements.
• Fine Chemical Synthesis: Employed in organic synthesis to create novel analogs for structure-activity relationship (SAR) studies.
• Academic Research: Utilized in university and institutional labs for metabolic engineering and natural product chemistry projects.

Basic Information

Product Name	Dihydromonacolin L
CAS No.	86827-77-2
Molecular Formula	C23H34O5
Molecular Weight	390.52 g/mol
Synonyms	Dihydromonacolin L; Monacolin L, Dihydro-; Dihydro-Monacolin L; (3R,5R)-7-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1-naphthyl]-3,5-dihydroxyheptanoic Acid; 2-Methylbutyric Acid (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthyl]ethyl]tetrahydro-2H-pyran-2,4-diyl Ester; L 154,803; Antibiotic L 154,803; ML-236B (dihydro derivative)
EINECS	Contact for details

Quality Control

Our Dihydromonacolin L is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.