Description

Benzyl-Peg5-Azide is a heterobifunctional polyethylene glycol (PEG) derivative featuring a benzyl ether group and a terminal azide functionality. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require reliable, high-purity linkers for creating novel drug conjugates, diagnostic probes, and functionalized hydrogels.

Application

• Bioconjugation and ADC Development: Serves as a versatile linker for attaching cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides in the synthesis of Antibody-Drug Conjugates (ADCs) and other biotherapeutics.
• Click Chemistry Reagent: The terminal azide group readily participates in copper-catalyzed (CuAAC) or strain-promoted (SPAAC) azide-alkyne cycloaddition reactions for labeling, surface modification, and polymer functionalization.
• PEGylation Agent: Used to introduce a hydrophilic PEG spacer (PEG5) to biomolecules, improving solubility, stability, and pharmacokinetic profiles while reducing immunogenicity.
• Material Science and Surface Engineering: Functionalizes nanoparticles, microspheres, and sensor surfaces to create bio-compatible platforms for drug delivery, diagnostics, and biosensing applications.
• Crosslinking and Hydrogel Formation: Acts as a building block or crosslinker in the synthesis of smart hydrogels and polymeric networks for tissue engineering and controlled release systems.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.

Basic Information

Product Name	Benzyl-Peg5-Azide
CAS No.	86770-72-1
Molecular Formula	C22H37N3O7
Molecular Weight	455.55 g/mol
Synonyms	1-Azido-3,6,9,12,15-pentaoxaheptadecan-17-yloxy-methylbenzene; Benzyl-PEG5-N3; Benzyl-O-(CH2CH2O)5-(CH2)2-N3; Azido-PEG5-Benzyl Ether; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl benzyl ether; Benzyl 17-azido-3,6,9,12,15-pentaoxaheptadecyl ether; PEG5-Benzyl Azide; N3-PEG5-O-Benzyl
EINECS	Contact for details

Quality Control

Our Benzyl-Peg5-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Azide Content (NMR/Titration)	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.