Description

Benzyl-Peg3-N3 CAS NO 86770-70-9 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a benzyl-protected terminus and a terminal azide group. This compound is a critical building block in modern bioconjugation and click chemistry strategies, enabling the precise and efficient coupling of molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as antibody-drug conjugate (ADC) development, peptide modification, and polymer functionalization.

Application

• Bioconjugation Reagent: A key intermediate for linking drugs, dyes, or other functional moieties to proteins, antibodies, or peptides via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC).
• Antibody-Drug Conjugate (ADC) Development: Used to construct the hydrophilic PEG spacer arm in ADCs, improving solubility and pharmacokinetic profiles of therapeutic conjugates.
• Polymer and Materials Science: Serves as a functional monomer or cross-linker for synthesizing smart hydrogels, surface coatings, and functionalized nanomaterials with azide handles.
• Proteomics and Chemical Biology: Facilitates the labeling and pull-down of biomolecules for activity-based protein profiling (ABPP) and other discovery research.
• Diagnostic Reagent Synthesis: Employed in the creation of contrast agents, fluorescent probes, and other diagnostic tools requiring specific, bio-orthogonal attachment.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile, cleavable linker for the synthesis of modified peptides and peptide-PEG conjugates.

Basic Information

Product Name	Benzyl-Peg3-N3
CAS No.	86770-70-9
Molecular Formula	C16H25N3O4
Molecular Weight	323.39 g/mol
Synonyms	1-Azido-3,6,9-trioxa-12-phenyl-12-dodecanol; 11-Azido-3,6,9-trioxa-11-phenylundecan-1-ol; Benzyl-PEG3-azide; Benzyl-tri(ethylene glycol)-azide; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]methyl]benzene; Azido-PEG3-benzyl ether; N3-PEG3-O-Benzyl; Benzyloxy-PEG3-azide
EINECS	Contact for details

Quality Control

Our Benzyl-Peg3-N3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.