Description

Azido-PEG6 is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group at one terminus and a hydroxyl group at the other. This compound is essential for creating stable, biocompatible conjugates in advanced bioconjugation and materials science applications. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: The azide group enables efficient, site-specific conjugation to alkynes via click chemistry (CuAAC or strain-promoted), making it a key reagent for constructing antibody-drug conjugates (ADCs) and protein-polymer hybrids.
• Peptide and Protein Modification: Used to introduce PEG spacers onto peptides or proteins, enhancing solubility, stability, and pharmacokinetic properties while reducing immunogenicity.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and microarray surfaces with azide groups for subsequent bio-orthogonal coupling of biomolecules.
• Polymer and Dendrimer Synthesis: Serves as a versatile building block in the synthesis of functionalized PEG-based polymers, dendrimers, and hydrogels for drug delivery systems.
• Crosslinking Agent: Acts as a hydrophilic spacer in crosslinking reactions to create three-dimensional networks for tissue engineering scaffolds and controlled-release matrices.
• Diagnostic Probe Synthesis: Utilized in the preparation of fluorescent or radioactive probes for imaging and diagnostic applications, leveraging the bio-orthogonal nature of azide chemistry.

Basic Information

Product Name	Azido-PEG6
CAS No.	86770-69-6
Molecular Formula	C18H37N3O7
Molecular Weight	407.5 g/mol
Synonyms	1-Azido-3,6,9,12,15,18-hexaoxahenicosan-21-ol; Azido-PEG6-OH; 21-Hydroxy-3,6,9,12,15,18-hexaoxahenicosyl azide; N3-PEG6-OH; PEG6-Azide; Hexaethylene glycol monoazide; Azido-hexaethylene glycol; Azido-PEG6-alcohol
EINECS	Contact for details

Quality Control

Our Azido-PEG6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Azide Content (NMR)	≥ 95% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.