Description

1-Azidohexaethylene Glycol is a specialized bifunctional polyethylene glycol (PEG) derivative featuring an azide group, making it a critical click chemistry reagent. This compound is essential for the efficient, modular, and bioorthogonal conjugation of molecules, particularly in aqueous environments. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and materials science industries for applications such as bioconjugation, polymer synthesis, and surface functionalization.

Application

• Bioconjugation and Labeling: Used as a linker to attach fluorophores, drugs, or other functional moieties to proteins, antibodies, or oligonucleotides via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• PEGylation and Drug Delivery: Serves as a hydrophilic, flexible spacer in the synthesis of PEGylated therapeutics to improve solubility, stability, and pharmacokinetic profiles.
• Polymer and Materials Science: A key monomer or cross-linker for creating functional hydrogels, smart materials, and surface coatings with tailored properties.
• Diagnostic Probe Development: Facilitates the construction of diagnostic assays and imaging probes by enabling specific, covalent attachment of targeting and signaling molecules.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the study of biomolecular interactions through site-specific labeling.
• Nanoparticle Functionalization: Used to modify the surface of nanoparticles (e.g., liposomes, quantum dots) for targeted delivery and biocompatibility.

Basic Information

Product Name	1-Azidohexaethylene Glycol
CAS No.	86770-68-5
Molecular Formula	C12H25N3O6
Molecular Weight	307.34 g/mol
Synonyms	Azido-PEG6-alcohol; 1-Azido-3,6,9,12,15,18-hexaoxahenicosan-21-ol; 2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; Hexaethylene glycol monoazide; N3-PEG6-OH; Azidohexaethylene glycol; Azido-PEG6-OH; 11-Azido-3,6,9-trioxaundecan-1-ol (related structure)
EINECS	Contact for details

Quality Control

Our 1-Azidohexaethylene Glycol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening to maintain product integrity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.