Description

4-((Trimethylsilyl)Ethynyl)Isoquinoline is a specialized organosilicon building block featuring a trimethylsilyl-protected ethynyl group attached to the isoquinoline core. This compound matters as a versatile intermediate for constructing complex molecular architectures in advanced organic synthesis and materials science. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and organic electronics industries for applications such as cross-coupling reactions and the synthesis of novel functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly those requiring alkyne functionalization for click chemistry or Sonogashira coupling.
• Agrochemical Research: Used in the development of new active ingredients and plant protection agents that incorporate heterocyclic and silicon-containing motifs.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers, organic semiconductors, and light-emitting materials due to the ethynyl linkage and isoquinoline unit.
• Ligand Synthesis: Employed in the preparation of novel ligands for catalysis, where the isoquinoline nitrogen can act as a coordinating site.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags where the alkyne handle allows for bioorthogonal labeling.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and constructing complex heterocyclic systems.

Basic Information

Product Name	4-((Trimethylsilyl)Ethynyl)Isoquinoline
CAS No.	86549-28-2
Molecular Formula	C₁₅H₁₇NSi
Molecular Weight	239.39 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)isoquinoline; 4-(2-Trimethylsilylethynyl)isoquinoline; 4-(Trimethylsilylethynyl)isoquinoline; 4-Ethynylisoquinoline, trimethylsilyl derivative; Isoquinoline, 4-[(trimethylsilyl)ethynyl]-; 86549-28-2
EINECS	Contact for details

Quality Control

Our 4-((Trimethylsilyl)Ethynyl)Isoquinoline is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications. We support cGMP and ISO standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.