Description

3-((Trimethylsilyl)Ethynyl)Isoquinoline is a versatile organosilicon building block featuring a trimethylsilyl-protected acetylene group attached to an isoquinoline core. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex heterocyclic systems. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the synthesis of complex drug candidates, especially those containing isoquinoline or extended π-conjugated systems.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the isoquinoline moiety imparts specific biological activity.
• Material Science: Acts as a precursor for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, planar structure and functional handle for further modification.
• Cross-Coupling Reactions: The protected alkyne group is a valuable substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand Synthesis: Utilized for preparing novel nitrogen-containing ligands for catalysis in asymmetric synthesis and transition metal complexes.
• Fluorescent Probe Development: The isoquinoline scaffold can be incorporated into molecules designed as sensors or imaging agents.

Basic Information

Product Name	3-((Trimethylsilyl)Ethynyl)Isoquinoline
CAS No.	86521-11-1
Molecular Formula	C₁₅H₁₇NSi
Molecular Weight	239.39 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]isoquinoline; 3-(2-Trimethylsilylethynyl)isoquinoline; 3-Isoquinolinyl(trimethylsilyl)acetylene; 1-Aza-3-[(trimethylsilyl)ethynyl]naphthalene; TMS-Ethynyl Isoquinoline; 86521-11-1; 3-(Trimethylsilylethynyl)isoquinoline
EINECS	Contact for details

Quality Control

Our 3-((Trimethylsilyl)Ethynyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.