Description

1-((Trimethylsilyl)Ethynyl)Isoquinoline is a specialized organosilicon building block featuring a reactive ethynyl group protected by a trimethylsilyl (TMS) moiety. This compound matters for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex heterocyclic scaffolds. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel isoquinoline-based drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in creating new pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Cross-Coupling Reactions: Acts as a TMS-protected acetylene equivalent in Sonogashira, Heck, and other palladium-catalyzed coupling reactions.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Used as a probe or tag in bioconjugation chemistry and the development of molecular imaging agents.

Basic Information

Product Name	1-((Trimethylsilyl)Ethynyl)Isoquinoline
CAS No.	86521-10-0
Molecular Formula	C₁₄H₁₇NSi
Molecular Weight	227.38 g/mol
Synonyms	1-[(Trimethylsilyl)ethynyl]isoquinoline; 1-(2-Trimethylsilylethynyl)isoquinoline; 1-Isoquinolyl(trimethylsilyl)acetylene; 1-(Trimethylsilylethynyl)isoquinoline; 1-Ethynyl-isoquinoline, trimethylsilyl ether; TMS-Ethynyl Isoquinoline; (Isoquinolin-1-ylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 1-((Trimethylsilyl)Ethynyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Light yellow to yellow solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.