Description

β-D-Glucopyranuronic Acid Methyl Ester Tetrakis(2,2-Dimethylpropanoate) is a high-purity, chemically modified carbohydrate derivative that serves as a critical advanced intermediate in organic synthesis. Its value lies in providing a protected and activated glucuronic acid scaffold, enabling precise chemical transformations for research and production. This compound is essential for pharmaceutical chemists, bioconjugation specialists, and manufacturers of fine chemicals, particularly in the development of prodrugs, targeted drug delivery systems, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel glucuronide prodrugs designed for targeted release and enhanced bioavailability.
• Bioconjugation Chemistry: Used to attach therapeutic payloads (e.g., drugs, toxins, imaging agents) to antibodies, proteins, or peptides via a cleavable glucuronic acid linker.
• Glycochemistry Research: Serves as a protected precursor for the controlled synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Enzyme Substrate & Inhibitor Development: Employed in the design and study of substrates or inhibitors for enzymes like β-glucuronidase, relevant in drug metabolism and activation.
• Fine Chemical Synthesis: Advanced intermediate for creating specialty chemicals with specific stereochemistry and functionalization for agrochemical or material science applications.

Basic Information

Product Name	β-D-Glucopyranuronic Acid Methyl Ester Tetrakis(2,2-Dimethylpropanoate)
CAS No.	86448-91-1
Molecular Formula	C31H50O13
Molecular Weight	630.73 g/mol
Synonyms	Methyl (2,3,4-Tri-O-pivaloyl-β-D-glucopyranosyluronate) Pivalate; Methyl 2,3,4-Tri-O-pivaloyl-1-O-(pivaloyl)-β-D-glucopyranosiduronate; 1-O-Pivaloyl-2,3,4-tri-O-pivaloyl-β-D-glucopyranuronic Acid Methyl Ester; Pivaloylated Methyl β-D-Glucuronate; β-D-Glucopyranuronic Acid, Methyl Ester, 1,2,3,4-Tetrakis(2,2-dimethylpropanoate); Methyl 1,2,3,4-Tetra-O-pivaloyl-β-D-glucopyranuronate
EINECS	Contact for details

Quality Control

Every batch of β-D-Glucopyranuronic Acid Methyl Ester Tetrakis(2,2-Dimethylpropanoate) is produced and tested under a strict quality management system. We guarantee high chemical purity and structural integrity, with comprehensive analysis via HPLC, NMR, and MS to confirm identity and assay. A detailed Certificate of Analysis (COA) documenting purity, impurity profile, and physical characteristics is provided with each shipment to support your R&D and cGMP-compliant manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.