Description

2'-o-(1,3-Benzodithiol-2-Yl)-3',5'-o-(1,1,3,3-Tetraisopropyldisiloxan-1,3-Diyl)Uridine is a sophisticated, high-purity nucleoside derivative, specifically engineered as a key protected intermediate in oligonucleotide synthesis. Its core value lies in enabling the precise and efficient construction of RNA sequences, which is fundamental for advanced research and therapeutic development. This compound is essential for pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on antisense technology, siRNA development, and other cutting-edge nucleic acid-based applications.

Application

• Oligonucleotide Synthesis: Serves as a critical, protected building block for the solid-phase synthesis of RNA strands, ensuring high coupling efficiency and fidelity.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides for gene silencing and targeting specific mRNA sequences.
• Pharmaceutical Intermediate: Acts as a vital precursor in the multi-step synthesis of novel nucleoside-based drug candidates and prodrugs.
• Bioconjugation & Probe Development: The benzodithiol protecting group offers potential for further functionalization, useful in creating labeled probes for diagnostic assays.
• Academic & Contract Research: Supports fundamental research in nucleic acid chemistry, molecular biology, and the study of RNA structure and function.

Basic Information

Product Name	2'-o-(1,3-Benzodithiol-2-Yl)-3',5'-o-(1,1,3,3-Tetraisopropyldisiloxan-1,3-Diyl)Uridine
CAS No.	86365-02-8
Molecular Formula	C31H46N2O7SSi2
Molecular Weight	671.0 g/mol
Synonyms	2'-O-(1,3-Benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine; 2'-O-(1,3-Benzodithiol-2-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine; Uridine, 2'-O-(1,3-benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-; 2'-BDT-3',5'-TIPS-uridine; 2'-O-Benzodithiol-3',5'-O-TIPDS-uridine; 2'-O-(1,3-Benzodithiol-2-yl)-3',5'-O-(TIPDS)uridine; 2'-O-(BDT)-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)uridine
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive oligonucleotide synthesis. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.