Description

Tolufazepam CAS NO 86273-92-9 is a benzodiazepine derivative belonging to a class of compounds with significant pharmacological interest. This high-purity chemical intermediate is critical for research and development in the pharmaceutical sector, particularly for studying structure-activity relationships and metabolic pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new benzodiazepine-based active pharmaceutical ingredients (APIs).
• Metabolic Pathway Studies: Used in preclinical research to investigate the biotransformation and pharmacokinetic profiles of benzodiazepine compounds.
• Analytical Reference Standard: Employed as a high-purity calibrant in analytical methods such as HPLC, LC-MS, and GC-MS for quality control and forensic analysis.
• Chemical Synthesis: Acts as a specialized building block for medicinal chemists exploring modifications to the benzodiazepine core structure to develop new chemical entities.
• Academic Research: Utilized in university and institutional laboratories for pharmacological and neurochemical research projects.

Basic Information

Product Name	Tolufazepam
CAS No.	86273-92-9
Molecular Formula	C₁₉H₁₇ClN₂O₂
Molecular Weight	340.80 g/mol
Synonyms	7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; Tolufazepam; 1-Methyl-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Ro 07-4065
EINECS	Contact for details

Quality Control

Our Tolufazepam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.